These microscope images show a chain of alternating blue and yellow droplets folding into a crown geometry through blue-blue, blue-yellow and finally yellow-yellow interactions, mediated by sticky DNA strands. Image: Brujic Lab.A team of physicists has created a new way to self-assemble particles – an advance that offers new promise for building complex and innovative materials at the microscopic level.
Self-assembly, introduced in the early 2000s, gives scientists a way to ‘pre-program’ particles, allowing for the building of materials without further human intervention – the microscopic equivalent of Ikea furniture that can assemble itself.
This new breakthrough, reported in a paper in Nature, centers on emulsions—droplets of oil immersed in water—and their use in the self-assembly of foldamers, which are unique shapes that can be theoretically predicted from the sequence of droplet interactions.
The self-assembly process borrows from the field of biology, mimicking the folding of proteins and RNA using colloids. The researchers created tiny, oil-based droplets in water, which possess an array of DNA sequences that serve as assembly ‘instructions’. These droplets first assemble into flexible chains and then sequentially collapse, or fold, via the sticky DNA molecules. This folding yields a dozen types of foldamers, and further could encode more than half of 600 possible geometric shapes.
“Being able to pre-program colloidal architectures gives us the means to create materials with intricate and innovative properties,” explains Jasna Brujic, a professor in New York University’s Department of Physics and one of the researchers. “Our work shows how hundreds of self-assembled geometries can be uniquely created, offering new possibilities for the creation of the next generation of materials.”
The scientists emphasize the counterintuitive, and pioneering, aspect of the method: rather than requiring a large number of building blocks to encode precise shapes, this folding technique means only a few are necessary because each block can adopt a variety of forms.
“Unlike a jigsaw puzzle, in which every piece is different, our process uses only two types of particles, which greatly reduces the variety of building blocks needed to encode a particular shape,” explains Brujic. “The innovation lies in using folding similar to the way that proteins do, but on a length scale 1000 times bigger – about one-tenth the width of a strand of hair. These particles first bind together to make a chain, which then folds according to pre-programmed interactions that guide the chain through complex pathways into a unique geometry.
“The ability to obtain a lexicon of shapes opens the path to further assembly into larger-scale materials, just as proteins hierarchically aggregate to build cellular compartments in biology.”
This story is adapted from material from New York University, with editorial changes made by Materials Today. The views expressed in this article do not necessarily represent those of Elsevier. Link to original source.